Facilities

Speke, Liverpool, UK

REAL-TIME
VIRTUAL FACILITY TOUR

Offering state-of-the-art biotech API production, including fermentation, spray drying, coating, and pre-mixing for human and animal health.

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Key Capabilities

  • Biotech API
  • Fermentation & Downstream Processing
  • API Pre-Mixing
  • API Spray Drying & Coating
  • Non-sterile Liquid Filling
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Located in the heart of one of the UK’s leading bioprocessing regions, the Speke facility is FDA-, MHRA-, FAMI-QS-, and SFSF-approved and offers robust human and animal health capabilities including biotech API production, fermentation & downstream processing, spray drying & coating, pre-mixing, and non-sterile liquid filling.

Facility Highlights

  • 320+ employees produce 135+ SKUs, directly supplying more than 65 global customers
  • Human and animal health manufacturing capabilities, including:
    • Biotech API production
    • Non-sterile liquid filling
  • Animal health manufacturing capabilities, including:
    • Fermentation & downstream processing
    • API Spray drying & coating
    • API Pre-Mixing
  • Shipping & warehousing
  • Extensive QC testing capabilities
  • FDA-, MHRA-, FAMI-QS-, and SFSF-approved

WORLD CLASS BIOTECH API
PRODUCTION, API PRE-MIXING &
NON-STERILE LIQUID FILLING

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Manufacturing, Filling & Packaging Capabilities

  • Biotech API

    • Fermentation - 6,000-liter fermenter
    • Granule isolation with Alfa Laval MB601 centrifuge & GEA NS5180H homogenizer
    • Purification with GE AxiChrom chromatography columns and Pall TFF units
    • Dried or frozen API using cold processing, product freezers & bulk tray freeze dryer
  • Fermentation & Downstream Processing

    • Culture preparation utilizing four independent culture suites
    • Fermentation with nineteen 150,000-, one 20,000-, and four 8,000-liter fermenters
    • Separation of solid phase & drying/milling to solid API
    • Membrane separation & concentration to liquid API
  • API Spray Drying

    • Spray drying of antibiotic & enzyme liquid concentrate using Niro automated fluidized bed spray dryers (units with 700,000kg/year and 100,000kg/year capacity)
    • Bulk keg packaging
  • API Pre-Mixing

    • Three independent premixing production areas enable the dilution of liquid and dry API with powder diluents for final product production
      • Dry API dilution using a 4,000kg blender—automated paper bag filling, multi-product capabilities
      • Liquid API dilution using blenders & Niro Aeromatic Dryers (T8-B7-F2)—filling to plastic form-fill bags, high potency containment available, multi-product capabilities
      • Liquid API dilution using product granulation technology—filled to paper sacks
  • API Spray Coating

    • Coating of powder API with protective excipient layer to create final product or coating API
    • Process completed using a Huttlin coater/dryer, sieve/milling, horizontal ribbon blender
    • Bag filling using an automated 25kg filler
  • Non-Sterile Liquid Filling

    • Formulation and filling of liquid API
    • Filling accomplished using a Serac filling machine capable of filling 100ml to 1000ml bottles in an ISO8 booth
    • Labels printed and automatically applied using a laser printer - serialization capability available